Microbial hydroxylation and reduction of the diterpene psiadin

作者：Orabi KY^*; Galal AM; Ibrahim ARS; El Feraly FS; McPhail AT

来源：Zeitschrift fur Naturforschung Section C-A Journal of Biosciences, 2001, 56(3-4): 216-222.

• psiadin
• microbial bioconversion
• 2 alpha-hydroxydeoxopsiadin

Microbial bioconversion studies conducted on the diterpene psiadin have revealed that it was metabolized by Aspergillus niger (NRRL 2295) to give 2 alpha -hydroxydeoxopsiadin, Cunninghamella blakesleeana (ATCC 8688a) to give 11 beta -hydroxypsiadin, and Cylindrocephalum aureum (ATCC 12720), Gongronella butleri (ATCC 22822), Kloeckera africana (ATCC 20111), and Kluyveromyces marxianus var, lactis (ATCC 2628) to yield 7 alpha -hydroxypsiadin. Their structures have been established on the basis of spectral data. The structure and relative stereochemistry of 7 alpha -hydroxypsiadin was confirmed by single-crystal X-ray analysis.

• 出版日期2001-4