Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner

作者：Miller Suzanne L^*; Sutherland Amy E; Supramaniam Veena G; Walker David W; Jenkin Graham; Wallace Euan M

来源：Reproduction, Fertility and Development, 2012, 24(5): 753-758.

DOI：10.1071/RD11143

• betamethasone
• fetal growth
• intrauterine growth restriction

Antenatal glucocorticoids are administered to mature the fetal lungs before preterm birth. Glucocorticoids also have non-pulmonary effects, including reducing fetal body and brain growth. The present study examined whether glucocorticoid administration has a sex-specific effect on growth in appropriately grown (control) and intrauterine growth-restricted (IUGR) fetal sheep. IUGR was induced at 0.7 gestation in fetal sheep by single umbilical artery ligation. On Days 5 and 6 after surgery, IUGR or control fetuses were exposed to the synthetic glucocorticoid betamethasone (BM; 11.4 mg) or saline via intramuscular maternal administration. On Day 7, a postmortem was conducted to determine fetal sex and weight. Compared with control fetuses, the birthweight of male and female IUGR fetuses was significantly reduced (by 18.5 +/- 4.4% (P = 0.002) and 21.7 +/- 6.0% (P = 0.001), respectively). Maternal administration of BM significantly reduced bodyweight in both control and IUGR fetuses (by 11.3 +/- 2.8% and 20.5 +/- 3.6% in control male and female fetuses, respectively; and by 22.9 +/- 3.1% and 38.3 +/- 3.4% in IUGR male and female fetuses, respectively; P %26lt; 0.001 for all, versus control + saline) fetuses. In control and IUGR animals the degree of growth restriction was greater in females than males (P %26lt; 0.05) following administration of BM. These data suggest that antenatal glucocorticoids reduce fetal growth in a sex-specific manner, with females more growth restricted than males.

• 出版日期2012
• 单位河北医科大学