Systemic lupus erythematosus activity and beta two microglobulin levels

作者：Skare Thelma Larocca^*; Ferri Kellen; Santos Marcela Aimone

来源：Sao Paulo Medical Journal, 2014, 132(4): 239-242.

DOI：10.1590/1516-3180.2014.1324703

• Lupus erythematosus, systemic
• beta 2-microglobulin
• Inflammation
• Blood sedimentation
• Acute-phase reaction

CONTEXT AND OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune disease with a cyclical clinical course. Evaluation of the clinical activity of this disease is important for choosing the correct treatment. The objective of this study was to analyze the value of beta-2 microglobulin (beta 2M) serum levels in determining SLE clinical activity.
DESIGN AND SETTING: Cross-sectional analytical study conducted at the rheumatology outpatient clinic of a private university hospital.
METHODS: 129 SLE patients were studied regarding disease activity using SLEDAI (SLE Disease Activity Index) and cumulative damage using SLICC ACR (SLE International Collaborating Clinics/American College of Rheumatology Damage Index for SLE). At the same time, the beta 2M serum level, ESR (erythrocyte sedimentation rate), anti-dsDNA (anti-double-stranded DNA) and C3 and C4 complement fractions were determined.
RESULTS: beta 2M levels correlated positively with SLEDAI (P = 0.02) and ESR (P = 0.0009) and negatively with C3 (P = 0.007). Patients who were positive for anti-dsDNA had higher beta 2M serum levels (P = 0.009).
CONCLUSION: beta 2M levels are elevated in SLE patients with active disease.

• 出版日期2014