科研之友
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摘要
1b and 2b with single and double chiral binaphthyl pockets have been used as asymmetric hydroxylation catalysts of benzylic C-H bonds. Both catalysts show quite different stoichiometric and enantioselective properties. Bis-faced bridged 2b exhibits enantiomeric excesses(e.e.) 58%similar to 79%, higher than ever reported catalytic systems. The corresponding mono-faced bridged 1b gives good e.e. value in the presence of nitrogen base ligand. Meanwhile, the solvent effect of the catalytic system can have a strong Influence on the e.e. value and alcohol/ketone ratio of the catalytic products.
- 出版日期2008-9
- 单位上海交通大学
