NHC-Catalyzed Reaction of Enals with Hydroxy Chalcones: Diastereoselective Synthesis of Functionalized Coumarins

作者:Bhunia Anup; Patra Atanu; Puranik Vedavati G; Biju Akkattu T*
来源:Organic Letters, 2013, 15(7): 1756-1759.
DOI:10.1021/ol400562z

摘要

The N-heterocyclic carbene-catalyzed annulation of enals with 2'-hydroxy chalcones afford cyclopentane-fused coumarin derivatives with an excellent level of diastereocontrol. The reaction tolerates a broad range of functional groups; 25 examples are given, and a preliminary mechanistic investigation is provided.

  • 出版日期2013-4-5