Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization

作者：Moon Hyung Geun; Kim Seung jae; Jeong Jong Jin; Han Seon Sook; Jarjour Nizar N; Lee Hyun; Abboud Werner Sherry L; Chung Sangwoon; Choi Hak Soo; Natarajan Viswanathan; Ackerman Steven J; Christman John W; Park Gye Young^*

来源：Immunity, 2018, 49(2): 275-+.

DOI：10.1016/j.immuni.2018.06.009

Airway epithelial cells (AECs) secrete innate immune cytokines that regulate adaptive immune effector cells. In allergen-sensitized humans and mice, the airway and alveolar microenvironment is enriched with colony stimulating factor-1 (CSF1) in response to allergen exposure. In this study we found that AEC-derived CSF1 had a critical role in the production of allergen reactive-IgE production. Furthermore, spatiotemporally secreted CSF1 regulated the recruitment of alveolar dendritic cells (DCs) and enhanced the migration of conventional DC2s (cDC2s) to the draining lymph node in an interferon regulatory factor 4 (IRF4)-dependent manner. CSF1 selectively upregulated the expression of the chemokine receptor CCR7 on the CSF1R(+) cDC2, but not the cDC1, population in response to allergen stimuli. Our data describe the functional specification of CSF1-dependent DC subsets that link the innate and adaptive immune responses in T helper 2 (Th2) cell-mediated allergic lung inflammation.

• 出版日期2018-8-21