科研之友
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摘要
A short synthetic sequence leading to the formation of the C,D,E-ring subunit of the Aspidosperma alkaloids is reported. This route is based on a ring, fragmentation/intramolecular azomethine ylide 1,3-dipolar-cycloaddition reaction sequence the gives the desired tricyclic product as a single diastereomer. A gamma-amino-beta-hydroxy-alpha-diazo carbonyl compound is shown to fragment in the presence of a Lewis acid to give an iminium product that can be directly reduced: to, the corresponding amine.
- 出版日期2016-8-19
