Association of dietary AGEs with circulating AGEs, glycated LDL, IL-1 alpha and MCP-1 levels in type 2 diabetic patients

作者：Chao Pei chun; Huang Chien ning; Hsu Cheng chin; Yin Mei chin^*; Guo Yu ru

来源：European Journal of Nutrition, 2010, 49(7): 429-434.

DOI：10.1007/s00394-010-0101-3

• Dietary AGEs
• Glycated LDL
• IL-1 alpha
• MCP-1

The association of dietary advanced glycation endproducts (AGEs) intake with the oxidative and inflammatory status in type 2 diabetic patients was examined.
Seventy-four healthy controls, 50 low AGEs intake and 68 high AGEs intake type 2 diabetic patients were requested to complete a 7-day dietary record. Blood levels of several oxidative and inflammatory biomarkers were determined.
Diabetic patients with high AGEs intake had significantly elevated plasma levels of AGEs, HbA1c, low-density lipoprotein (LDL), LDL-cholesterol and glycated LDL than low AGEs intake patients and controls (P < 0.05). These high AGEs intake patients also had significantly increased plasma levels of 8-isoprostane, interleukin (IL)-1 alpha, tumor necrosis factor-alpha, monocyte chemoattractant protein (MCP)-1 and lower superoxide dismutase (SOD) activity than low AGEs intake patients (P < 0.05). Correlation coefficients of dietary AGEs versus plasma AGEs, HbA1c, 8-isoprostane, IL-1 alpha and MCP-1 were > 0.6; but the correlation coefficient of dietary AGEs versus plasma SOD activity was <-0.6.
Increasing dietary AGEs intake might enrich circulating AGE level and contribute to oxidative and inflammatory progression under diabetic condition. The circulating 8-isoprostane, IL-1 alpha and MCP-1 levels and SOD activity might be appropriate biomarkers used to evaluate dietary AGEs-associated oxidative and inflammatory stress.

• 出版日期2010-10
• 单位中国医科大学