Associations between common genetic polymorphisms in the liver X receptor alpha and its target genes with the serum HDL-cholesterol concentration in adolescents of the HELENA Study

作者：Legry Vanessa; Bokor Szilvia; Beghin Laurent; Galfo Myriam; Gonzalez Gross Marcela; Molnar Denes; Moreno Luis A; Amouyel Philippe; Dallongeville Jean; Meirhaeghe Aline^*

来源：Atherosclerosis, 2011, 216(1): 166-169.

DOI：10.1016/j.atherosclerosis.2011.01.031

• HDL-cholesterol
• Lipid
• LXR alpha
• ABCA1
• Polymorphism
• Association study
• Adolescents

Objective: Genetic variability in the NR1H3 gene (encoding LXR alpha) and in several of its target genes is associated with serum HDL-cholesterol (HDL-C) concentrations. We sought to assess if these associations could be detected in adolescents.
Methods: Thirty-nine polymorphisms in NR1H3, ABCA1, APOE, CETP, PLTP and LPL were analysed in the HELENA study (n = 1144 European adolescents).
Results: The minor alleles of rs11039155 in NR1H3, rs2575879 in ABCA1, rs708272, rs17231506 and rs5882 in CETP and rs328 in LPL were associated with higher serum HDL-C concentrations (p <= 0.0012). The minor alleles of rs12221497 in NR1H3, rs1800978 in ABCA1 and the APOE epsilon 4 allele were associated with lower HDL-C concentrations (p <= 0.01). The combined set of associated polymorphisms accounted for similar to 6.6% of the variance in HDL-C.
Conclusion: We report for the first time that polymorphisms in NR1H3 and its target genes ABCA1, APOE, CETP and LPL contribute to the genetic variance for HDL-C concentrations in adolescence.

• 出版日期2011-5