The inhibitory effect of β-elemene alone or combined with chemotherapy on diffuse large B cell lymphoma cell strain OCI-LY8 in vitro

作者：Li, Dan; Wu, Xueyong; Liang, Xiaohua^*

来源：Biomedical Research-India, 2017, 28(12): 5418-5422.

• beta-elemene
• DLBCL strain
• PCNSL

Objective: To investigate the inhibitory effect of beta-Elemene alone or combined with chemotherapy drugs on diffuse large B cell lymphoma cell strain OCI-LY8 in vitro. @@@ Methods: The optimum cytotoxic concentration of beta-Elemene was determined by MTT method. After combining different concentrations of beta-Elemene with chemotherapy drugs, the cell death rate was calculated according to the OD values in 24 h, 48 h and 72 h, respectively. The data was analysed using SPSS 13.0. All tests were conducted in triplicate. @@@ Results: The inhibitory effect of beta-Elemene combined with VM-26 was relatively stronger under the same condition. But in the different time interval unites the cell death rate showed non-statistics difference between the five different chemotherapy drugs, P>0.05. @@@ Conclusion: Single drug of beta-Elemene could induce apoptosis tumor cells to a certain extent, and also there was synergized action combined with chemotherapy drugs; but there were no significant differences between these drugs when combined with beta-Elemene.

• 出版日期2017
• 单位复旦大学