Feasibility and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction

作者：Takano Hiroyuki; Hasegawa Hiroshi; Kuwabara Yoichi; Nakayama Takashi; Matsuno Koki; Miyazaki Yoshiya; Yamamoto Masashi; Fujimoto Yoshihide; Okada Hisayuki; Okubo Shinji; Fujita Miwa; Shindo Satoshi; Kobayashi Yoshio; Komiyama Nobuyuki; Takekoshi Noboru; Imai Kamon; Himi Toshiharu; Ishibashi Iwao; Komuro Issei^*

来源：International Journal of Cardiology, 2007, 122(1): 41-47.

DOI：10.1016/j.ijcard.2006.11.016

• G-CSF
• myocardial infarction
• remodeling
• myocardial perfusion
• restenosis

Background: This study examined feasibility and safety of granulocyte colony- stimulating factor ( G- CSF) treatment for patients with acute myocardial infarction ( AMI).
Methods: Forty patients with AMI related with the left anterior descending coronary artery, who underwent successful percutaneous coronary intervention ( PCI), were randomized into G- CSF group ( n= 18) or Control group ( n= 22). G- CSF treatment was started within 24 h after PCI. Tc-99m- tetrofosmin single- photon emission computed tomography ( SPECT) was performed at 4 days and 6 months after AMI. SPECT data was analyzed for LV end- diastolic volume ( LVEDV), LV end- systolic volume ( LVESV), LV ejection fraction ( LVEF) and myocardial perfusion.
Results: LVEF at 6 months was significantly better than that at 4 days in G- CSF group ( p= 0.013), but not changed in Control group ( p= 0.245). Although no significant difference was observed for LVEDV between the two groups, LVESV tended to be decreased only in G-CSF group. In G- CSF group, defect score ( DS) was significantly decreased from 4 days to 6 months after AMI. Restenosis rate at 6 months after AMI was not significantly different between the two groups.
Conclusions: G- CSF treatment for patients with AMI was effective and did not have any clinical and angiographic adverse effects.

• 出版日期2007-10