A Facile Solid-Phase Synthesis of (+)-(S)-Clopidogrel

作者:Jung Kiwon; Kim Jae Sun; Kim Tae Hyun; Kim Jinwoong
来源:Helvetica Chimica Acta, 2013, 96(2): 326-329.

摘要

Enantiomerically pure (+)-(S)-clopidogrel was prepared by solid-phase synthesis using the commercially available Wang resin. This method offers mild reaction conditions and provides the (+)-(S)-clopidogrel in overall 52% yield over six steps and with optical purity of 98.0% ee.

  • 出版日期2013-2