Systematic fetal autopsy in cases of medical termination of pregnancy due to chromosomal abnormalities: improving the quality of perinatal care?

作者：Ramalho C^*; Brandao O; Matias A; Montenegro N

来源：Prenatal Diagnosis, 2010, 30(10): 1000-1004.

DOI：10.1002/pd.2605

• chromosomal abnormalities
• prenatal ultrasound
• prenatal diagnosis
• termination of pregnancy
• fetal autopsy

Objectives Evaluation of the clinical utility of systematically performing autopsy after termination of pregnancy (TOP) due to chromosomal abnormalities
Methods A retrospective study of cases of TOP due to chromosomal abnormalities was performed between 1 January 2002 and 30 September 2007, in a tertiary referral hospital A comparative study between prenatal ultrasonographic findings and postmortem findings was performed
Results There were 57 cases of TOP (hie to chromosomal abnormalities The median gestational age at TOP was 17 (range 14-24 weeks) There were 46 trisomies, 4 monosomies, 4 triploidies and 3 cases of structural anomalies In 25 cases (43 9%) there was at least one major anomaly detected by ultrasound In 15 cases (26 3%) additional information was obtained alter fetal autopsy. m 7 cases further major structural anomalies were detected, and in 8 cases the presence of a major abnormality was not confirmed by the autopsy
Conclusion Fetal autopsy may provide additional information to the ultrasonographic morphological evaluation of the fetus submitted to TOP clue to chromosomal abnormalities. The combination of prenatal ultrasound and pathological examination can broaden our knowled

• 出版日期2010-10