An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

作者：Dagdas Yasin F; Belhaj Khaoula; Maqbool Abbas; Chaparro Garcia Angela; Pandey Pooja; Petre Benjamin; Tabassum Nadra; Cruz Mireles Neftaly; Hughes Richard K; Sklenar Jan; Win Joe; Menke Frank; Findlay Kim; Banfield Mark J; Kamoun Sophien; Bozkurt Tolga O

来源：eLife, 2016, 5: e10856.

DOI：10.7554/eLife.10856

Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.

• 出版日期2016-1-14