Atorvastatin causes regression of endometriotic implants in a rat model

作者：Yilmaz Bulent^*; Ozat Mustafa; Kilic Sevtap; Gungor Tayfun; Aksoy Yasemin; Lordlar Nese; Sut Necdet; Aksakal Orhan

来源：Reproductive BioMedicine Online, 2010, 20(2): 291-299.

DOI：10.1016/j.rbmo.2009.11.004

• atorvastatin
• rat endometriosis model
• superoxide dismutase
• VEGF
• MMP-9
• TIMP-2

Endometriotic implants were induced surgically in female Wistar albino rats, which were randomly divided into three groups. The rats in group I (n = 10) and group II (n = 9) were given 2.5 mg/kg/day intraperitoneal and oral atorvastatin, respectively, for 28 days. Group III (n = 9) was given no medication (control). The mean volume and weight of explants in group I were significantly lower (both P < 0.05) compared with group III. Histopathological score of the implants was significantly tower in groups I and II, when compared with group III (P < 0.01 and P < 0.05, respectively). There were significant reductions in explant concentrations of vascular endothelial growth factor and matrix metalloproteinase 9 in group I (P < 0.01 and P < 0.001, respectively) and group II (both P < 0.01) compared with group III while staining due to tissue inhibitor of metalloproteinase 2 was significantly higher in group I (P < 0.01) and group II (P < 0.01) compared with group III. Moreover, explant concentration of superoxide dismutase was significantly increased in groups I and II compared with group III (both P < 0.05). In conclusion, atorvastatin causes significant regression of endometriotic implants in rats. Moreover, intraperitoneal atorvastatin seems to be more effective than oral atorvastatin.

• 出版日期2010-2