Ultrasound promoted one pot synthesis of novel fluorescent triazolyl spirocyclic oxindoles using DBU based task specific ionic liquids and their antimicrobial activity

作者：Singh Harjinder; Sindhu Jayant; Khurana Jitender M^*; Sharma Chetan; Aneja K R

来源：European Journal of Medicinal Chemistry, 2014, 77(2): 145-154.

DOI：10.1016/j.ejmech.2014.03.016

• Multicomponent reactions
• Ultrasonic irradiation
• Ionic liquids
• 1,2,3-Triazole
• Antimicrobial activity

Spirocyclic oxindoles and triazolyl derivatives posses remarkable biological activities. In present work, we have described an efficient one pot four-component domino reaction of 1-(prop-2-ynyl)indoline-2,3-dione, cyclic 1,3-diketones, malononitrile and various aryl azides in DBU based ionic liquids [DBU-H]OAc and [DBU-Bu]OH under ultrasonic irradiation for the construction of heterocycles, comprising spiro-oxindole, 2-amino-4H-pyran, and 1,2,3-triazoles substructures. The antimicrobial activity of all compounds has been investigated against six microbial strains. All compounds showed good antimicrobial activity. All newly synthesized compounds exhibit fluorescence in methanol with large stoke shift.

• 出版日期2014-4