科研之友
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摘要
The asymmetric conjugate addition of malonate esters to alpha,beta-unsaturated N-sulfonyl imines is catalyzed by PyBOX/La(OTf)(3) complexes in the presence of 4 angstrom MS. The reaction gives the corresponding E enamines bearing a stereogenic center at the allylic position with good yields and enantiomeric ratios up to 97:3. This reaction provides a synthetic entry to chiral delta-aminoesters and piperidones.
- 出版日期2013-10-25
