Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat Meal

作者：Harvey Jennifer C; Roseguini Bruno T; Goerger Benjamin M; Fallon Elizabeth A; Wong Brett J^*

来源：Journal of Diabetes Research, 2016, 2016: 1902325.

DOI：10.1155/2016/1902325

We tested the hypothesis that a high fat meal (HFM) would impair cutaneous vasodilation, while thermotherapy (TT) would reverse the detrimental effects. Eight participants were instrumented with skin heaters and laser-Doppler (LD) probes and tested in three trials: control, HFM, and HFM + TT. Participants wore a water-perfused suit perfused with 33 degrees C (control and HFM) or 50 degrees C (HFM + TT) water. Participants consumed 1 g fat/kg body weight. Blood samples were taken at baseline and two hours post-HFM. Blood pressure was measured every 5-10 minutes. Microvascular function was assessed via skin local heating from 33 degrees C to 39 degrees C two hours after HFM. Cutaneous vascular conductance (CVC) was calculated and normalized to maximal vasodilation (%CVCmax). HFM had no effect on initial peak (48 +/- 4 % CVCmax) compared to control (49 +/- 4 % CVCmax) but attenuated the plateau (51 +/- 4 % CVCmax) compared to control (63 +/- 4 % CVCmax, P < 0.001). Initial peak was augmented in HFM + TT (66 +/- 4 % CVCmax) compared to control and HFM (P < 0.05), while plateau (73 +/- 3 % CVCmax) was augmented only compared to the HFM trial (P < 0.001). These data suggest that HFM negatively affects cutaneous vasodilation but can be minimized by TT.

• 出版日期2016