Association of sleep quality in Behcet disease with disease activity, depression, and quality of life in Korean population

作者：Lee Jimin; Kim Sung Soo; Jeong Hye Jin; Son Chang Nam; Kim Ji Min; Cho Yong Won; Kim Sang Hyon^*

来源：Korean Journal of Internal Medicine, 2017, 32(2): 352-359.

DOI：10.3904/kjim.2016.367

• Behcet syndrome
• Sleep quality

Background/Aims: Sleep disturbance is prime concern in patients with Behcet disease. The purpose of this study was to find out the effects of sleep quality, in Korean patients suffering from Behcet disease. We further investigated the relationship between depression, quality of life and the clinical findings of Behcet disease.
Methods: The study was performed by the cross-sectional design. Sleep quality was assessed by the Korean version of Pittsburgh sleep quality index (PSQI). Disease activity of Behcet disease was evaluated by Behcet disease current activity form (BDCAF). Depression was assessed by the Korean version of Beck depression inventory second edition (BDI-2). Quality of life was assessed by the Korean version of the Leeds Behcet disease quality of life measure (BDQoL).
Results: Among the 100 patients studied, 42% reported poor sleep quality (PSQI >= 9). These patients have a higher BDI-2, total BDCAF and pain visual analogue scale (VAS) score (p < 0.001, p = 0.022, and p = 0.005). Considering BDCAF, the frequency of genital ulcer was significantly higher (p = 0.01). Behcet was higher in females. The BDQoL was lower in poor sleeper group (p = 0.004 and p < 0.001). Among 7 PSQI components, daytime dysfunction was higher in patients with high disease activity (p = 0.03). Total PSQI score were strongly correlated with BDCAF, BDI-2, BDQoL, and pain VAS score (p = 0.02, p < 0.001, p < 0.001, and p < 0.001, respectively).
Conclusions: Low sleep quality is directly associated with disease activity, depression, and quality of life in Korean patients with Behcet disease.

• 出版日期2017-3