An Electrochemical Sensing Strategy for Amantadine Detection Based on Competitive Host-guest Interaction of Methylene Blue/beta-cyclodextrin/Poly(N-acetylaniline) Modified Electrode

作者：Hao, Xia; Li, Na; Xu, Zhen; Li, Nian Bing^*; Luo, Hong Qun^*

来源：Electroanalysis, 2016, 28(7): 1489-1494.

DOI：10.1002/elan.201501149

• Amantadine
• beta-Cyclodextrin
• Host-guest interaction
• Methylene blue

A novel electrochemical strategy for the detection of amantadine (AMD) has been developed based on the competitive host-guest interaction of AMD and methylene blue (MB) with beta-cyclodextrin (beta-CD). Due to the host-guest interaction, MB molecules can enter into the hydrophobic inner cavity of beta-CD, and the MB/beta-CD/poly(N-acetylaniline)/glassy carbon electrode displays a remarkable reduction peak due to MB. In the presence of AMD, competitive association to beta-CD occurs and the MB molecules are displaced by AMD, resulting in a decrease of reduction peak current of MB. The difference value of the cathodic peak current showed a linear relationship with the AMD concentration.

• 出版日期2016-7
• 单位西南大学