Anti-inflammatory, Antioxidant and Cytotoxicity Activities of Methanolic Extract and Prenylated Flavanones Isolated from Leaves of Eysehardtia platycarpa

作者：Dominguez Villegas Valeri; Dominguez Villegas Vanessa; Luisa Garcia Maria; Calpena Ana; Clares Naveros Beatriz; Luisa Garduno Ramireza Maria

来源：Natural Product Communications, 2013, 8(2): 177-180.

DOI：10.1177/1934578x1300800211

• Flavanones
• Eysenhardtia platycarpa
• Anti-inflammatory activity
• Antioxidant activity
• cytotoxic activity
• Artemia salina

From the methanolic extract of Eysenhardtia platycarpa (leaves), were isolated the prenylated flavanones: 5,7-dihydroxy-6-methyl-8-prenylflavanone (1), 5,7-dihydroxy-6-methyl-8-prenyl-4%26apos;-methoxy-flavanone (2), 5,7-dihydroxy-6-prenylflavanone (3), 5-dihydroxy-7-methoxy-6-prenylflavanone (4), 5,7-dihydroxy-8-prenyl-4%26apos;-methoxy-flavanone (5). Methanolic extract of E. platycarpa (leaves) and flavanones (5), (2) and (3) showed anti-inflammatory activity according to tested quantities. In addition, flavanone (5) revealed the best percentage reduction of free radical DPPH. Finally, after cytotoxic activity study, the methanolic extract from E. platycarpa leaves and flavanone (4) exhibited promising cytotoxic activity on brine shrimp.

• 出版日期2013-2