Adolescents' Psychosocial Health-Related Quality of Life Within 6 Months After Cancer Treatment Completion

作者：Ruccione Kathleen^*; Lu Yani; Meeske Kathleen

来源：Cancer Nursing, 2013, 36(5): E61-E72.

DOI：10.1097/NCC.0b013e3182902119

• Adolescence
• Adolescent cancer survivors
• Cancer survivorship
• Coping behaviors
• Health-related quality of life (HRQOL)
• Patient-reported outcomes (PRO)
• Pediatric oncology

Background:
Health-related quality of life (HRQOL) may be affected by cure-directed therapy given to pediatric oncology patients. Identification of HRQOL risk/protective factors may facilitate the development of clinical interventions.
Objective:
The study purpose was to assess adolescents' psychosocial HRQOL soon after treatment completion using patient-reported outcome measures.
Methods:
Subjects were recruited from May 2005 to February 2007 to participate in a structured interview that collected information on demographics, symptoms, HRQOL (PedsQL 4.0), and coping (Adolescent Coping Orientation for Problem Strategies Questionnaire). Disease/treatment information was abstracted from medical records. Data analysis included descriptive approaches for data summarization and regression modeling for estimation and testing.
Results:
A total of 94 participants were included in the analyses. Their mean psychosocial functioning summary scores fell between the means reported for healthy children and children with cancer; 18% were more than 1 standard deviation below the mean. In the univariate analyses, lower psychosocial HRQOL was associated with central nervous system tumors (P = .01), radiation therapy (P = .01), and treatment duration of 13 to 24 months (P < .01). Protective factors identified in multivariable analyses included older age and use of humor for coping; risk factors included symptoms of pain, fatigue, and posttraumatic stress.
Conclusion:
Although most patients rated their psychosocial HRQOL as good, a subset (18%) may have increased risk for impaired HRQOL.
Implications for Practice:
Clinical assessment of psychosocial HRQOL using patient-reported outcome measures during the early posttreatment phase is recommended. Longitudinal studies are needed to further explore risk/protective factors and to identify targeted interventions to minimize the adverse psychosocial effects of cancer treatment and maximize healthy survivorship.

• 出版日期2013-10