Neuropeptide Y and leptin receptor expression in the hypothalamus of rats with chronic immobilization stress(star star star star star star star)star

作者：Wang Shaoxian; Chen Jiaxu^*; Yue Guangxin; Bai Minghua; Kou Meijing; Jin Zhongye

来源：Neural Regeneration Research, 2013, 8(18): 1721-1726.

DOI：10.3969/j.issn.1673-5374.2013.18.010

• neural regeneration
• chronic immobilization stress
• hypothalamus
• arcuate nucleus
• double immunofluorescence
• neuropeptide Y
• leptin receptor
• feeding center
• body weight
• grants-supported paper
• neuroregeneration

In this study, Sprague-Dawley rats were immobilized to a frame for 3 hours a day for 21 days to establish a model of chronic immobilization stress. The body weight and food intake of rats subjected to chronic immobilization stress were significantly decreased compared with the control group. Dual-labeling immunofluorescence revealed that the expression of leptin receptor and the co-localization coeffient in these leptic receptor neurons in the arcuate nucleus of the hypothalamus were both upregulated, while the number of neuropeptide Y neurons was decreased. Chronic immobilization stress induced high expression of leptin receptor in the arcuate nucleus and suppressed the synthesis and secretion of neuropeptide Y, thereby disrupting the pathways in the arcuate nucleus that regulate feeding behavior, resulting in diminished food intake and reduced body weight.

• 出版日期2013-6
• 单位北京中医药大学; 中国中医科学院中医基础理论研究所