Novel branched isocyanides as useful building blocks in the Passerini-amine deprotection-acyl migration (PADAM) synthesis of potential HIV-1 protease inhibitors

作者：Gravestock David; Rousseau Amanda L; Lourens Anna C U; Hoppe Heinrich C; Nkabinde Lindiwe A; Bode Moira L^*

来源：Tetrahedron Letters, 2012, 53(26): 3225-3229.

DOI：10.1016/j.tetlet.2012.04.018

• Multi-component coupling reaction
• Passerini
• Acyl migration
• PADAM
• HIV-1 protease

Novel branched isocyanides have been prepared from L-serine and used as building blocks in the Passerini-amine deprotection-acyl migration (PADAM) sequence for the preparation of compounds with activity against HIV-1 protease.

• 出版日期2012-6-27