Upregulation of ZBTB7A exhibits a tumor suppressive role in gastric cancer cells

作者：Sun, Guang^*; Peng, Bo; Xie, Quan; Ruan, Jianwen; Liang, Xianwen

来源：Molecular Medicine Reports, 2018, 17(2): 2635-2641.

DOI：10.3892/mmr.2017.8104

• gastric cancer
• zinc finger and BTB domain containing 7A
• apoptosis
• migration
• cell cycle

Gastric cancer presents as a complex solid tumor and is the third leading cause of global cancer-associated mortality. The genetic alterations in gastric cancer remain unclear and deserve further investigation. Mining The Cancer Genome Atlas gastric adenocarcinoma dataset identified a frequent loss of the zinc finger and BTB domain containing 7A (ZBTB7A) gene locus and a significant correlation between low ZBTB7A expression and poor patient survival. ZBTB7A belongs to the POZ/BTB and Kruppel transcription factor family. In the present study, overexpression of ZBTB7A in a gastric cancer cell line induced cell cycle arrest at the S phase. Upregulation of ZBTB7A also promoted apoptosis and repressed cell migration. The results of the present study indicated that ZBTB7A functions as a tumor suppressor in gastric cancer cells. Understanding the role of ZBTB7A in gastric cancer may provide important clinical insight for treatment.

• 出版日期2018-2
• 单位中南大学