Association between chemokine receptor 5 (CCR5) delta32 gene variant and atherosclerosis: a meta-analysis of 13 studies

作者：Zhang, Zhongwen; Liu, Ju; Wang, Huanjun; Wu, Hongxia; Wu, Xuanmei; Dong, Jianjun; Liao, Lin^*

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(1): 658-665.

• CCR5
• gene polymorphism
• atherosclerosis
• meta-analysis

Background: Chemokine receptor 5 (CCR5) is one of the pro-inflammatory G protein coupled receptors. Many studies have accessed the association between CCR5 gene polymorphism and atherosclerotic disease. However, the results are conflicting and inconclusive. The aim of this study was to evaluate the association more precisely. Research Design and Methods: Trials were retrieved through Pubmed, Embase, Medline, China National Knowledge Infrastructure, Web of Science, and Cochrane database without restrictions on language. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to describe the strength of association with atherosclerotic disease. The subgroup analysis was used to explore the heterogeneity bias among studies. Results: Data were obtained from 13 case-control studies that included 5321 patients with atherosclerotic disease and 4283 control subjects. In the overall analysis, the CCR5-delta32 (Delta 32) genetic variants was not associated with increased the risk of atherosclerotic disease (dominant model: OR = 0.93, 95% CI = 0.69-1.24, I-2 = 77%, P = 0.60; recessive model: OR = 1.01, 95% CI = 0.61-1.65, I-2 = 0%, P = 0.98), even after stratification for the status of CCR5-delta32 allele. However, in subgroup analysis, the association was significant for Asians population (OR: 2.29, 95% CI: 1.44-3.64, P = 0.0004). Conclusions: Our studies add to the evidence that CCR5 Delta 32-positive genotype (Delta 32/Delta 32 or wt/Delta 32) increases the risk of atherosclerotic disease in Asian population. Ethnicity difference might contribute to the inconsistency in isolated studies.

• 出版日期2015
• 单位山东大学; 山东省千佛山医院