ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries

作者：Filipovic Nenad^*; Rosic Mirko; Tanaskovic Irena; Milosevic Zarko; Nikolic Dalibor; Zdravkovic Nebojsa; Peulic Aleksandar; Kojic Milos R; Fotiadis Dimitris I; Parodi Oberdan

来源：IEEE Transactions on Information Technology in Biomedicine, 2012, 16(2): 272-278.

DOI：10.1109/TITB.2011.2168418

• Atherosclerosis
• low-density lipoprotein (LDL)
• plaque
• wall shear stress

Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.

• 出版日期2012-3