Novel Synthesis of Tryptamine Derived 4-Hydroxy-4-arylthiazolidine-2-thiones and 4-Arylthiazole-2(3H)-thiones by Multicomponent Reactions

作者：Devi Nepram Sushuma; Singh Sarangthem Joychandra; Mahiya Kuldeep; Singh Okram Mukherjee^*; Choi Hojune; Lee Sang Gyeong^*

来源：BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2016, 37(9): 1472-1477.

DOI：10.1002/bkcs.10892

• Multicomponent reaction
• Thiazolidine-2-thione
• Thiazole 2-thione
• Tryptamine
• Phenacyl bromide

An efficient one-pot multicomponent synthesis of 3-(2-(1H-indol-3-yl)ethyl)-4-hydroxy-4-arylthiazolidine-2-thione and 3-(2-(1H-indol-3-yl)ethyl)-4-arylthiazole-2(3H)-thione has been developed from a multicomponent reaction of tryptamine, carbon disulfide and phenacyl bromide. This protocol has an advantage such as operational simplicity, short reaction time, and affording good to excellent yields.

• 出版日期2016-9