Antioxidant, anticancer and electrochemical redox properties of new bis(2,3-dihydroquinazolin-4(1H)-one) derivatives

作者：Sivaguru Paramasivam; Parameswaran Kandasamy; Lalitha Appaswami^*

来源：Molecular Diversity, 2017, 21(3): 611-620.

DOI：10.1007/s11030-017-9748-5

• Bis(2,3-dihydroquinazolin-4(1H)-one)
• Antioxidant
• DPPH radical scavenging activity
• Anticancer
• Redox potential

In this paper, a series of bis(2,3-dihydroquinazolin4(1H)-one) derivatives (4a-i, 10a-k) were synthesized by the one-pot pseudo-five-component reaction of isatoic anhydride with aromatic aldehydes and aromatic amines under reflux in glacial acetic acid. The synthesized compounds were screened for their antioxidant properties using the DPPH radical scavenging method. Compounds 4i and 10h showed potent radical scavenging activities at 20 mu g/mL compared to BHA and ascorbic acid. The anticancer activity of compound 4f was evaluated against human breast cancer cell line (MCF 7), and the observed GI(50) was found to be 11.4 mu m. The redox behaviour of some analogues was evaluated by cyclic voltammetric methods, and it is found that compound 7d possesses the maximum redox potential.

• 出版日期2017-8