A novel preparation of methyl-beta-cyclodextrin from dimethyl carbonate and beta-cyclodextrin

作者：Gan Yongjiang; Zhang Yumin^*; Xiao Chuanhao; Zhou Chunyan; Zhao Yucang

来源：Carbohydrate Research, 2011, 346(3): 389-392.

DOI：10.1016/j.carres.2010.05.028

• beta-Cyclodextrin
• Dimethyl carbonate
• Methyl-beta-cyclodextrin
• NMR
• MS

A novel green synthesis process about methyl-beta-cyclodextrin has been investigated through the reaction between beta-cyclodextrin and dimethyl carbonate by anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including the molar ratio of dimethyl carbonate to beta-cyclodextrin, reaction temperature, and reaction time on the average degree of substitution of methyl-beta-cyclodextrin was studied. The results show that the average degree of substitution of methyl-beta-cyclodextrin can be dependent on the reaction temperature and the molar ratio of raw material primarily. The structures of methyl-beta-cyclodextrin were characterized by TLC, IR, MS, (1)H NMR, and (13)C NMR.

• 出版日期2011-2-15
• 单位天津大学