Multicomponent reaction through cooperative trio catalysis incorporating enamine, Bronsted acid and metal Lewis acid catalysis: a concise route to access chromans

作者:Karunaratne Chamini V; Sarkisian Ryan G; Reeves Jennifer; Deng Yongming; Wheeler Kraig A; Wang Hong*
来源:Organic and Biomolecular Chemistry, 2017, 15(23): 4933-4936.
DOI:10.1039/c7ob00753a

摘要

An atom-economical multicomponent cascade reaction of salicyl-aldehydes, cyclohexanones and arylamines has been developed for the synthesis of three-ring fused chromans. This reaction was achieved through cooperative enamine-metal Lewis acid assisted Bronsted acid catalysis, furnishing the products in excellent yields with good diastereoselectivity.

  • 出版日期2017-6-21