Difference of fibroblast growth factor receptor 1 expression among CA1-3 regions of the gerbil hippocampus after transient cerebral ischemia

作者：Yoo Ki Yeon; Hwang In Koo; Lee Choong Hyun; Choi Jung Hoon; Kwon Seung Hae; Kang Il Jun; You Sang Guan; Kim Young Myeong; Won Moo Ho^*

来源：Journal of the Neurological Sciences, 2010, 296(1-2): 13-21.

DOI：10.1016/j.jns.2010.06.018

• Ischemia
• Hippocampus
• Fibroblast growth factor receptor 1
• Glial fibrillary acidic protein
• Astrocytes
• Gerbil

Fibroblast growth factors are important regulators of neuronal development. In this study, we observed fibroblast growth factor receptor 1 (FGFR1) immunoreactivity and its protein levels in the hippocampus proper (CA1-3 regions) of the gerbil at various time points after ischemia/reperfusion. In the sham-operated group, FGFR1 immunoreaction was not detected in the hippocampus proper. FGFR1 immunoreaction was first detected in non-pyramidal neurons in the CA1-3 region at 12 h and 1 day after ischemia/reperfusion. From 2 days after ischemia/reperfusion, FGFR1 immunoreaction was found in astrocytes, not in microglial cells, in the CA1 region: FGFR1 immunoreactivity and the number of astrocytes were significantly increased at 5 days post-ischemia. Western blot analysis revealed that FGFR1 protein levels were also increased from 1 day after ischemia/reperfusion. These results indicate that increase of FGFR1 in astrocytes of the ischemic CA1 region may be associated with gliosis followed by delayed neuronal death.

• 出版日期2010-9-15