Antinociceptive activity and chemical composition of constituents from Caragana microphylla seeds

作者：Huo, Y.; Guo, C.; Zhang, Q. -Y.; Chen, W. -S.; Zheng, H. -C.; Rahman, K.; Qin, L. -P.^*

来源：Phytomedicine, 2007, 14(2-3): 143-146.

DOI：10.1016/j.phymed.2006.03.008

• Caragana microphylla Lam.
• antinociceptive activity
• triterpenes
• alkaloid
• flavone
• isoflavone

This investigation was undertaken to ascertain the antinociceptive activity of Caragana microphylla Lam. seeds and isolate and characterize the constituents. Antinociceptive activity was screened using acetic acid-induced abdominal constriction in ICR mice. The 75% ethanol extract and some fractions showed analgesic activity, but the antinociceptive activity of chloroform fraction was the strongest and was more productive than other fractions. Seven compounds were isolated from it and identified as: (1) machaeric acid, (2) beta-sitosterol, (3) stigmasterol, (4) pratol, (5) dehydrocavidine, (6) formononetin and (7) sucrose. Caragana microphylla Lam. seeds showed analgesic activity, with the chloroform fraction showing the strongest analgesic activity among the fractions.

• 出版日期2007
• 单位天津市中医药研究院附属医院; 中国人民解放军第二军医大学; 上海交通大学