Mitochondria and reactive oxygen species

作者：Kowaltowski Alicia J; de Souza Pinto Nadja C; Castilho Roger F; Vercesi Anibal E^*

来源：Free Radical Biology and Medicine, 2009, 47(4): 333-343.

DOI：10.1016/j.freeradbiomed.2009.05.004

• Mitochondria
• Oxidative stress
• Free radicals
• Respiration
• Uncoupling
• Electron transport chain
• Energy metabolism

Mitochondria are a quantitatively relevant source of reactive oxygen species (ROS) in the majority of cell types. Here we review the sources and metabolism of ROS in this organelle, including the conditions that regulate the production of these species, such as mild uncoupling, oxygen tension, respiratory inhibition, Ca(2 ) and K( ) transport, and mitochondrial content and morphology. We discuss substrate-, tissue-, and organism-specific characteristics of mitochondrial oxidant generation. Several aspects of the physiological and pathological roles of mitochondrial ROS production are also addressed.

• 出版日期2009-8-15