An Efficient Four-Component, One-Pot Synthesis of 6-Amino-4-Aryl-3-Methyl-2,4-Dihydropyrano[2,3-C]Pyrazole-5-Carbonitriles Under Phase-Transfer Catalyst

作者：Ablajan Keyume^*; Wang Liju; Tuoheti Anagu; Kelimu Yakefujiang

来源：Letters in Organic Chemistry, 2012, 9(9): 639-643.

• Four-component reaction
• one-pot synthesis
• phase-transfer catalysis
• pyrano[2,3-c] pyrazole

A series of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles (5a-5j) were synthesized by four-component one-pot reaction of methyl acetoacetate (or ethyl acetoacetate), hydrazine hydrate, arylaldehydes and malononitrile in the presence of phase transfer catalyst. A highest yield of product was obtained while using 30 mol % of HDBAC as a catalyst.

• 出版日期2012-11
• 单位新疆大学