Nickel-dependent metalloenzymes

作者：Boer Jodi L; Mulrooney Scott B; Hausinger Robert P^*

来源：Archives of Biochemistry and Biophysics, 2014, 544: 142-152.

DOI：10.1016/j.abb.2013.09.002

• Nickel
• Enzyme
• Metallocenter
• Catalytic mechanism
• Protein structure

This review describes the functions, structures, and mechanisms of nine nickel-containing enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase, [NiFe]-hydrogenase, carbon monoxide dehydrogenase, acetyl-coenzyme A synthase/decarbonylase, methyl-coenzyme M reductase, and lactate racemase. These enzymes catalyze their various chemistries by using metallocenters of diverse structures, including mononuclear nickel, dinuclear nickel, nickel-iron heterodinuclear sites, more complex nickel-containing clusters, and nickel-tetrapyrroles. Selected other enzymes are active with nickel, but the physiological relevance of this metal specificity is unclear. Additional nickel-containing proteins of undefined function have been identified.

• 出版日期2014-2-15