Blood pressure control in ultra-early basal ganglia intracerebral hemorrhage

作者：Gong F T; Yu L P; Gong Y H; Zhang Y X; Wang Z G; Yan C Z^*

来源：European Review for Medical and Pharmacological Sciences, 2015, 19(3): 412-415.

• Intracerebral hemorrhage (ICH)
• Strengthened antihypertensive
• Hematoma expansion
• Cerebral edema
• Matrix metalloproteinase-9

OBJECTIVE: We performed this study to investigate the effect of blood pressure control in ultra-early basal ganglia intracerebral hemorrhage.
PATIENTS AND METHODS: 120 patients with ultra-early basal ganglia intracerebral hemorrhage were randomly divided into experimental group (strengthened antihypertensive) and control (normal antihypertensive). Each group consists of 60 patients, whose contractive pressure were controlled by intravenous antihypertensive drugs among 130-140 mmHg and 160-180 mmHg respectively for 24h, after 1h of beginning treatment. They were all evaluated by NIH Stroke Scale (NIHSS) before and after the treatment. Cranial CT, hematoma volume, hematoma enlargement, edema volume, serum matrix metalloproteinase-9 level were performed and compared between groups.
RESULTS: After 24h, hematoma volume and hematoma enlargement in the experimental group was significantly lower than control (p < 0.05). After 14 days, NIHSS score in the experimental group was significantly lower than control (p < 0.05). Cerebral edema amount and serum MMP-9 level in the experimental group were significantly lower than control after 5 days and 14 days.
CONCLUSIONS: Ultra-early basal ganglia intracerebral hemorrhage can remarkably reduce hematoma enlargement, cerebral edema, serum MMP-9 level, and improve the neurological function.

• 出版日期2015
• 单位山东大学