A simplified tether model for molecular motor transporting cargo

作者：Li Fang Zhen^*; Jiang Li Chun

来源：Chinese Physics B, 2010, 19(2): 020503.

DOI：10.1088/1674-1056/19/2/020503

• molecular motor
• Brownian ratchet
• symmetric linear potential
• motor-cargo system

Molecular motors are proteins or protein complexes which function as transporting engines in biological cells. This paper models the tether between motor and its cargo as a symmetric linear potential. Different from Elston and Peskin's work for which performance of the system was discussed only in some limiting cases, this study produces analytic solutions of the problem for general cases by simplifying the transport system into two physical states, which makes it possible to discuss the dynamics of the motor-cargo system in detail. It turns out that the tether strength between motor and cargo should be greater than a threshold or the motor will fail to transport the cargo, which was not discussed by former researchers yet. Value of the threshold depends on the diffusion coefficients of cargo and motor and also on the strength of the Brownian ratchets dragging the system. The threshold approaches a finite constant when the strength of the ratchet tends to infinity.

• 出版日期2010-2
• 单位山东财经大学